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Time to start of the next line of therapy was defined as the time from the date of randomization to the date of initiation dose of the next line of antineoplastic therapy following study treatment or death due to any cause, whichever occurs first.

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Time to end of the next line of therapy is defined as the time from the date of randomization to the date of last dose of the next line of antineoplastic therapy following study treatment or death due to any cause, whichever occurs first. Duration of the next line of therapy is defined as the time from the date of the first dose of the next line of therapy to the date of the last dose of the next antineoplastic therapy following study treatment or death due to any cause, whichever occurs first.

Degree of correlation will be determined between 2 methodologies for MRD assessment 8-color flow cytometry, next-generation sequencing and bone marrow aspirates and blood samples. High-risk population will include but not be limited to participants carrying deletion del 17, t , t , amplification ampl 1q, del13, or del1p. The ECOG performance is a 6-point scale used by doctors to assess how a participant's disease is progressing, how the disease affects the participant's daily life, and to determine appropriate treatment and prognosis.

Peripheral neuropathy is defined as the treatment-emergent adverse event in the high-level term of peripheral neuropathies not elsewhere classified NEC according to Medical Dictionary for Regulatory Activities MedDRA. Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Inclusion Criteria: Adult male or female participants 18 years or older with a confirmed diagnosis of symptomatic multiple myeloma according to standard criteria.

Vincristine, Adriamycin [doxorubicin], and dexamethasone VAD is not an acceptable induction therapy for this trial. Started screening no earlier than 75 days after transplant, completed screening within 15 days, and randomized no later than days after transplant. Must have not received post-ASCT consolidation therapy. ECOG performance status of 0 to 2. Female participants who: If they are of childbearing potential, agree to practice 2 effective methods of contraception, at the same time, from the time of signing the informed consent through 90 days after the last dose of study drug, AND Must also adhere to the guidelines of any treatment-specific pregnancy prevention program, if applicable, OR Agree to practice true abstinence, when this is in line with the preferred and usual lifestyle of the participant.

Periodic abstinence [eg, calendar, ovulation, symptothermal, postovulation methods for the female partner] and withdrawal are not acceptable methods of contraception. Male participants, even if surgically sterilized ie, status postvasectomy , who: Agree to practice effective barrier contraception during the entire study treatment period and through 90 days after the last dose of study drug, AND Must also adhere to the guidelines of any treatment-specific pregnancy prevention program, if applicable, OR Agree to practice true abstinence, when this is in line with the preferred and usual lifestyle of the participant.

Voluntary written consent must be given before performance of any study-related procedure not part of standard medical care, with the understanding that consent may be withdrawn by the participant at any time without prejudice to future medical care.